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Showing 1–8 of 8 results
Advanced filters: Author: Roman Belle Clear advanced filters

  • Histone modifications, such as Nε-lysine acetylation and methylation, play critical roles in regulating eukaryotic transcription. Now, the oxidation of acetyl-lysine to hydroxyacetyl-lysine of a select histone has been identified as a distinct modification catalysed by the human JmjC histone demethylase KDM3A, which plays a role in the cellular hypoxic response.

    • Roman Belle
    • John-Paul Bukowski
    • Christopher J. Schofield
    ResearchOpen Access
    Nature Chemistry
    Volume: 18, P: 823-834

  • An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

    • Morten E. Allentoft
    • Martin Sikora
    • Eske Willerslev
    ResearchOpen Access
    Nature
    Volume: 625, P: 301-311

  • Nε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone Nε-methyllysine readers and erasers can manifest selectivity is of fundamental and medicinal interest. Here, the authors study the phosphonium analogue of Nε-trimethyllysine, finding that a subtle substitution from nitrogen to phosphorus substantially affects its interactions with Nε-methyllysine readers and erasers.

    • Roman Belle
    • Jos J. A. G. Kamps
    • Jasmin Mecinović
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-11

  • The ten-eleven translocation (TET) dioxygenase subfamily catalyse the sequential oxidation of 5-methylcytosine (5mC) in DNA and belong to the Fe(II)-/2-oxoglutarate (2OG)-dependent dioxygenases that use 2OG and O2 cofactors to yield succinate and CO2. Here, the authors profile the TET-catalysed 5mC DNA oxidation and 2OG decarboxylation using MS and 1H NMR spectroscopy methods, revealing a high degree of substrate oxidation-independent 2OG turnover in TETs.

    • Klemensas Šimelis
    • Roman Belle
    • Akane Kawamura
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-9