Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Roman Galetto Clear advanced filters

  • Herpes simplex virus establishes lifelong latency in ganglionic neurons, which are the source for recurrent infection. Here Aubert et al. report a promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases, which leads to a significant reduction in ganglionic HSV loads and HSV reactivation.

    • Martine Aubert
    • Daniel E. Strongin
    • Keith R. Jerome
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • CD123, the interleukin-3 receptor alpha chain, is aberrantly expressed in acute myeloid leukemia blasts and leukemia stem cells. Here the authors report the design and characterize the anti-tumor activity of allogeneic CD123-targeted CAR-T cells as a therapeutic approach for acute myeloid leukemia.

    • Mayumi Sugita
    • Roman Galetto
    • Monica L. Guzman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy derived from the precursors of plasmacytoid dendritic cells. Here the authors characterize the anti-tumor activity of allogeneic anti-CD123 CAR-T cells in preclinical models of BPDCN.

    • Tianyu Cai
    • Agnès Gouble
    • Marina Konopleva
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • Shipra Das
    • Julien Valton
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16