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Showing 1–2 of 2 results
Advanced filters: Author: Romin Roshan Clear advanced filters

  • The T cell response to Kaposi sarcoma-associated herpesvirus is critical to controlling infection and immunopathology but has been poorly explored in immunocompetent patients. Here the authors characterise the T cell response to the Kaposi sarcoma-associated herpesvirus proteome in immunocompetent patients from rural Uganda.

    • Angela Nalwoga
    • Romin Roshan
    • Denise Whitby
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Kaposi sarcoma associated herpesvirus (KSHV) and Epstein Barr virus often co-infect hosts and some malignancies, such as primary effusion lymphoma, are typically arising from dual-infected cells. Here authors recapitulate dual infection in a humanized mouse model, and find that under these conditions, an efficient and specific CD8+ T cell response is mounted against the lytic KSHV antigen K6.

    • Nicole Caduff
    • Lisa Rieble
    • Christian Münz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13