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Showing 1–2 of 2 results
Advanced filters: Author: Ron Benyair Clear advanced filters

  • Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.

    • Avital Eisenberg-Lerner
    • Ron Benyair
    • Yifat Merbl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Marina Shenkman et al. show that the ERAD mannosidases EDEM1 and EDEM2 have bona fide mannosidase activity in vitro. The activity of these enzymes is substantially faster when their glycoprotein substrates are in the unfolded state, suggesting a mechanism for efficient ERAD targeting of unfolded or misfolded glycoproteins.

    • Marina Shenkman
    • Efrat Ron
    • Gerardo Z. Lederkremer
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11