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Showing 1–9 of 9 results
Advanced filters: Author: Ron S. Boger Clear advanced filters

  • Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

    • Alexander Teumer
    • Yong Li
    • Anna Köttgen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19

  • This study presents a protein search framework with conformal prediction, enabling statistically reliable annotation of protein function. The method improves homology search, enzyme classification, and filters proteins for further characterization.

    • Ron S. Boger
    • Seyone Chithrananda
    • Jennifer A. Doudna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Generating RNA sequences with improved function remains challenging. Here, authors present an RNA database for RNA structural and functional analysis. They use this database and the RNA generative models to identify RNA mutations that increase the thermostability of a bacterial ribosome.

    • Yekaterina Shulgina
    • Marena I. Trinidad
    • Jamie H. D. Cate
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • Jonathan Marten
    • Anna Köttgen
    Research
    Nature Genetics
    Volume: 51, P: 1459-1474