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Showing 1–2 of 2 results
Advanced filters: Author: Ronak Ghanbari-Azarnier Clear advanced filters

  • Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-clinical model.

    • Philip E. D. Chung
    • Deena M. A. Gendoo
    • Eldad Zacksenhaus
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Distinguishing the drivers of metastasis versus those of the primary tumour in breast cancer remains challenging. Here, the authors explore primary-only, metastatic-only, and shared drivers in breast cancer using mammary-specific transposon mutagenesis screens, which leads to potential therapeutic targets to prevent metastasis.

    • Zhe Jiang
    • YoungJun Ju
    • Eldad Zacksenhaus
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22