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Showing 1–6 of 6 results

Advanced filters: Author: Ronald B. Realubit Clear advanced filters

A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient

Jeremy B. Chang
Kayla M. Quinnies
Nicholas P. Tatonetti
ResearchOpen Access21 Jul 2016
Scientific Reports

Volume: 6, P: 1-5
A community computational challenge to predict the activity of pairs of compounds

A community computational challenge generates algorithms to predict activity of drug combinations.

Mukesh Bansal
Jichen Yang
Andrea Califano
Research17 Nov 2014
Nature Biotechnology

Volume: 32, P: 1213-1222
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

This study presents OncoTreat, a framework for the prioritization of compounds targeting mechanistic tumor dependencies in individual patients.

Mariano J. Alvarez
Prem S. Subramaniam
Andrea Califano
Research18 Jun 2018
Nature Genetics

Volume: 50, P: 979-989
PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens

Despite the importance of pharmacological and functional genomic screens the readouts are of low complexity. Here the authors introduce PLATE-Seq, a low-cost genome-wide mRNA profiling method to complement high-throughput screening.

Erin C. Bush
Forest Ray
Peter A. Sims
ResearchOpen Access24 Jul 2017
Nature Communications

Volume: 8, P: 1-7
Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’

Mariano J. Alvarez
Pengrong Yan
Andrea Califano
Correspondence23 Sept 2019
Nature Genetics

Volume: 51, P: 1427-1428
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.

Pasquale Laise
Megan L. Stanifer
Mariano J. Alvarez
ResearchOpen Access19 Jul 2022
Communications Biology

Volume: 5, P: 1-12