Approximately one-third of follicular thyroid carcinomas containPAX8–PPARG gene fusions, which result in the production of an oncogenic Pax 8–PPAR-γ fusion protein (PPFP). Here, Raman and Koenig describe the structure and function of PAX8 and PPARGand their protein products. They discuss possible mechanisms underlying the oncogenic action of PPFP and highlight the potential of PPFP as a diagnostic marker in thyroid nodule evaluation and as a therapeutic target.
- Priyadarshini Raman
- Ronald J. Koenig
