Production of complex machines such as the ribosome requires coordinated regulation of the components. A widely conserved plant regulator of alternative splicing on the TFIIIA transcription factor mRNA has been found. The RNA structurally mimics the 5S rRNA and, accordingly, binds ribosomal protein L5, which thus affects splicing and production of TFIIIA. As TFIIIA is needed for transcription of the 5S rRNA, this work defines a regulatory circuit for coordinating 5S rRNA production by its binding protein.
- Ming C Hammond
- Andreas Wachter
- Ronald R Breaker
