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Showing 1–4 of 4 results
Advanced filters: Author: Ronan Kapetanovic Clear advanced filters

  • This study presents the assembly and analysis of the genome sequence of a female domestic Duroc pig and a comparison with the genomes of wild and domestic pigs from Europe and Asia; the results shed light on the evolutionary relationship between European and Asian wild boars.

    • Martien A. M. Groenen
    • Alan L. Archibald
    • Lawrence B. Schook
    ResearchOpen Access
    Nature
    Volume: 491, P: 393-398

  • Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.

    • Xuan Sun
    • Benjamin Cao
    • Susan K. Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.

    • Lin Luo
    • Nilesh J. Bokil
    • Matthew J. Sweet
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Macrophages are innate immune sentinels providing frontline defence against infection. This Review describes the inducible mechanisms used by macrophages to kill bacterial pathogens and/or inhibit their growth and outlines how this knowledge might be exploited in the design of host-directed therapies.

    • Matthew J. Sweet
    • Divya Ramnath
    • Ronan Kapetanovic
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 92-107