Nature Search

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.

Huaqiang Zhou
Yi Hu
Ningning Zhou
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-11
A dedicated hypothalamic oxytocin circuit controls aversive social learning

In mice, the neural mechanisms underlying aversive social learning, specifically avoidance and fear after defeat, involve oxytocin signalling in the anterior subdivision of the ventromedial hypothalamus, ventrolateral part.

Takuya Osakada
Rongzhen Yan
Dayu Lin
Research24 Jan 2024
Nature

Volume: 626, P: 347-356
Antagonistic circuits mediating infanticide and maternal care in female mice

ESR1-expressing cells in the principal nucleus of the bed nucleus of stria terminalis are necessary, sufficient and naturally activated during infanticide, and they form reciprocal inhibition with the maternal cells to control young-directed behaviours in female mice.

Long Mei
Rongzhen Yan
Dayu Lin
Research07 Jun 2023
Nature

Volume: 618, P: 1006-1016
A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

Epstein–Barr virus-associated gastric cancer shows a robust response to immune checkpoint inhibitors. Here the authors introduce a deep convolutional neural network and its fusion with pathologists for predicting it from histopathology.

Xueyi Zheng
Ruixuan Wang
Muyan Cai
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-12
Engineered bacterial orthogonal DNA replication system for continuous evolution

Tian et al. developed a bacterial orthogonal DNA replication system by harnessing the temperate phage GIL16 DNA replication machinery, which provides a powerful tool for continuous evolution in prokaryotic cells.

Rongzhen Tian
Runzhi Zhao
Yanfeng Liu
Research13 Jul 2023
Nature Chemical Biology

Volume: 19, P: 1504-1512
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/USP deubiquitinase complexes.

Hui Song
Chunyuan Zhao
Wei Zhao
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-11
A hypothalamic pathway that suppresses aggression toward superior opponents

To fight or not to fight? Wei et al. show that Esr1 cells in the mouse cMPOA encode the fighting capability of male opponents and use this information to suppress aggression toward superior opponents by inhibiting attack-mediating ventromedial hypothalamus cells.

Dongyu Wei
Takuya Osakada
Dayu Lin
Research10 Apr 2023
Nature Neuroscience

Volume: 26, P: 774-787
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

Ying Qin
Qi Li
Wei Zhao
ResearchOpen Access09 Aug 2021
Nature Communications

Volume: 12, P: 1-9
Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency

Kunpeng Li
Rongzhen Zhang
Rong Xiao
ResearchOpen Access08 Jun 2017
Scientific Reports

Volume: 7, P: 1-11

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