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Showing 1–5 of 5 results
Advanced filters: Author: Ronit Freeman Clear advanced filters
  • Actuators based on DNA–inorganic hybrid crystals reversibly change shape, which can be programmed by the length and composition of the DNA polymer, and induce cascaded reactions of compartmentalized enzymes in response to external stimuli.

    • Yuan Gao
    • Wenzheng Shi
    • Ronit Freeman
    Research
    Nature Nanotechnology
    Volume: 20, P: 1813-1821
  • The extracellular matrix can affect cell behaviour both physically and biochemically. Here, the authors developed a substrate that is based on peptides and nucleic acids hybrids that can dynamically present signals upon demand which regulate cell adhesion and migration, thereby controlling cell organisation.

    • Ronit Freeman
    • Nicholas Stephanopoulos
    • Samuel I. Stupp
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11
  • Assembly of amyloids is important in neurodegenerative diseases, but there is limited understanding of how supramolecular chirality is controlled. Here, the authors report the design of peptide derivatives that allow chirality inversion at biologically relevant temperatures.

    • Stephen J. Klawa
    • Michelle Lee
    • Ronit Freeman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Predicting and controlling the functions in self-organized biomolecular nanostructures is a major challenge in systems biology. Now researchers have developed DNA scaffolds for the topological organization of different enzymes or cofactor-enzyme pairs. The organization of the biomolecules leads to the activation of enzyme cascades that do not occur in non-organized mixtures, and the reactivity of the system can be controlled by the DNA template.

    • Ofer I. Wilner
    • Yossi Weizmann
    • Itamar Willner
    Research
    Nature Nanotechnology
    Volume: 4, P: 249-254
  • Advances in the development of cytoskeletal-like materials with modular structures and mechanics are pivotal for the engineering of synthetic cells. Now actin-mimetic supramolecular peptide networks have been designed using programmable peptide–DNA crosslinkers, giving rise to tunable tactoid-shaped bundles and mechanical properties that control spatial localization, the diffusion of payloads and shape changes within artificial cells.

    • Margaret L. Daly
    • Kengo Nishi
    • Ronit Freeman
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1229-1239