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Showing 1–2 of 2 results
Advanced filters: Author: Ronny Nienhold Clear advanced filters

  • The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progression

    • Ronny Nienhold
    • Yari Ciani
    • Kirsten D. Mertz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Liquid biopsy is a novel promising, but technically challenging tool in oncology. We compared various circulating DNA extraction and sequencing systems used within four Swiss laboratories. Results were highly congruent, with perfect sensitivity down to 1% mutation frequency. We also determined several key factors to validate when implementing such tests.

    • Thibaud Koessler
    • Viola Paradiso
    • Thierry Nouspikel
    Research
    Laboratory Investigation
    Volume: 100, P: 1475-1484