Isocitrate dehydrogenase 1/2 mutant (IDHmt) astrocytomas are characterized by a scarcity of T cells, but their phenotypes and functionality are lesser known. Here authors provide an integrative approach to describe the immune microenvironment of these tumors and show that gemistocytic tumor cells, a cell type abundant in the tumor stroma surrounding perivascular T cell accumulations, generate a glial scarring-like functional state, responsible for T cell exclusion.
- Levi van Hijfte
- Marjolein Geurts
- Reno Debets
