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Showing 1–10 of 10 results
Advanced filters: Author: Rosa Thorolfsdottir Clear advanced filters

  • Rosa Thorolfsdottir et al. report a genome-wide association study of atrial fibrillation in 29,502 cases and 767,760 controls from Iceland and the UK Biobank. They identify a significant association with coding variants in RPL3L, the first ribosomal gene implicated in atrial fibrillation, and MYZAP, an intercalated disc gene.

    • Rosa B. Thorolfsdottir
    • Gardar Sveinbjornsson
    • Kari Stefansson
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-9

  • Understanding the underlying pathophysiology of obesity can help prevent this condition. Here, the authors perform a GWAS of BMI in diverse ancestries, finding four missense variants in FRS3 that affect BMI.

    • Andrea B. Jonsdottir
    • Gardar Sveinbjornsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Genome-wide association analyses using parental and offspring genotypes provide insights into fetal and maternal genetic effects on fetal growth. The results show that maternal and fetal genomes influence birth weight through distinct mechanisms.

    • Thorhildur Juliusdottir
    • Valgerdur Steinthorsdottir
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 53, P: 1135-1142

  • On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

    • Ioanna Ntalla
    • Lu-Chen Weng
    • Patricia B. Munroe
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.

    • Kristjan Norland
    • Gardar Sveinbjornsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Large-scale association analyses identify 142 independent risk variants for atrial fibrillation. Pathway and functional enrichment analyses suggest that many of the putative risk genes act via cardiac structural remodeling.

    • Jonas B. Nielsen
    • Rosa B. Thorolfsdottir
    • Cristen J. Willer
    Research
    Nature Genetics
    Volume: 50, P: 1234-1239

  • Genome-wide analyses identify loci associated with nonalcoholic fatty liver disease, including rare, protective loss-of-function variants in MTARC1 and GPAM. Plasma proteomic analyses provide insight into proteins involved in disease pathogenesis.

    • Gardar Sveinbjornsson
    • Magnus O. Ulfarsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1652-1663

  • Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS.

    • Anna Helgadottir
    • Gudmar Thorleifsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Holm, Ivarsdottir, Olafsdottir et al. compare symptoms and physical measures between Icelanders post SARS-CoV-2 infection with uninfected controls. From reported symptoms, they estimate the prevalence of long COVID as 7% at a median of 8 months after infection, while objective differences between cases and controls in the physical measures were few.

    • Hilma Holm
    • Erna V. Ivarsdottir
    • Kari Stefansson
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-13