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Showing 1–4 of 4 results
Advanced filters: Author: Rosalba Minelli Clear advanced filters

  • Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.

    • Roxsan Manshouri
    • Etienne Coyaud
    • Don L. Gibbons
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Next generation sequencing allows the identification of oncogenic driver genes in pancreatic cancer. Here, in an effort to identify additional causal genes, the authors develop a high throughput in vivoscreen and identify genes that whilst infrequently mutated in pancreatic cancer contribute to tumour formation.

    • Yiu Huen Tsang
    • Turgut Dogruluk
    • Kenneth L. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

    • Giannicola Genovese
    • Alessandro Carugo
    • Lynda Chin
    Research
    Nature
    Volume: 542, P: 362-366