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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Edy Y Kim
John T Battaile
Michael J Holtzman
Research18 May 2008
Nature Medicine

Volume: 14, P: 633-640
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Holtzman and colleagues identify PARP9-DTX3L as an E3 ubiquitin ligase complex that interacts with STAT1 to modify chromatin accessibility for expression in interferon-stimulated genes and to target viral proteases for degradation.

Yong Zhang
Dailing Mao
Michael J Holtzman
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1215-1227

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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

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