Nature Search

Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy

Differentiation therapy induces the maturation and clearance of acute myeloid leukemia cells. Here, using a mouse model, the authors show that a specific lineage of mature leukemia-derived cells persists during remission and is responsible for disease relapse.

Steven Ngo
Ethan P. Oxley
Ross A. Dickins
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-14
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour distances from experimental single-protein position data with those obtained from simulations based on a model of protein oligomerisation.

Luciano A. Masullo
Rafal Kowalewski
Ralf Jungmann
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-11
Erratum: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue
Lars Zender
Scott W. Lowe
Amendments and Corrections26 May 2011
Nature

Volume: 473, P: 544
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.

Marcus Lefebure
Richard W. Tothill
Ricky W. Johnstone
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-10
Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

Almudena R. Ramiro
Mila Jankovic
Michel C. Nussenzweig
Research08 Jan 2006
Nature

Volume: 440, P: 105-109
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

One of two papers showing that reactivation of the endogenous p53 tumour suppressor genes in established tumours causes cancer regression. In some tumours, p53 reactivation causes cellular senescence associated with an innate immune response that contributes to tumour clearance.

Wen Xue
Lars Zender
Scott W. Lowe
Research24 Jan 2007
Nature

Volume: 445, P: 656-660
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-catenin.

Quentin Van Thillo
Jolien De Bie
Charles E. de Bock
ResearchOpen Access06 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

Lai N. Chan
Zhengshan Chen
Markus Müschen
Amendments and Corrections30 May 2018
Nature

Volume: 558, P: E5
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

The lipid kinase PI3KC2α is essential for embryogenesis, yet its role in adult homeostasis is unknown. Here, the authors show that PI3KC2α regulates the structure of the internal membrane reserves of murine megakaryocytes and platelets, affecting the platelets’ adhesiveness and prothrombotic function.

Jessica K. Mountford
Claire Petitjean
Shaun P. Jackson
Research17 Mar 2015
Nature Communications

Volume: 6, P: 1-14
Stage-specific control of early B cell development by the transcription factor Ikaros

The transcription factor Ikaros is required for lymphopoiesis. Busslinger and colleagues show Ikaros positively regulates genes encoding pre-BCR signal transducers and thereby promotes pro-B to pre-B cell progression and proliferation.

Tanja A Schwickert
Hiromi Tagoh
Meinrad Busslinger
Research09 Feb 2014
Nature Immunology

Volume: 15, P: 283-293
The genomic landscape of hypodiploid acute lymphoblastic leukemia

Linda Holmfeldt, Lei Wei et al. report whole-genome and exome sequencing of 40 childhood hypodiploid acute lymphoblastic leukemias.

Linda Holmfeldt
Lei Wei
Charles G Mullighan
Research20 Jan 2013
Nature Genetics

Volume: 45, P: 242-252
Metabolic gatekeeper function of B-lymphoid transcription factors

The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.

Lai N. Chan
Zhengshan Chen
Markus Müschen
Research13 Feb 2017
Nature

Volume: 542, P: 479-483
Tissue-specific and reversible RNA interference in transgenic mice

Ross A Dickins
Katherine McJunkin
Scott W Lowe
Research17 Jun 2007
Nature Genetics

Volume: 39, P: 914-921
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

Ross A Dickins
Michael T Hemann
Scott W Lowe
Research02 Oct 2005
Nature Genetics

Volume: 37, P: 1289-1295
T-ALL can evolve to oncogene independence

Hesham Abdulla
Anh Vo
Matthew P. McCormack
Research22 Jan 2021
Leukemia

Volume: 35, P: 2205-2219
A pipeline for the generation of shRNA transgenic mice

Lukas E Dow
Prem K Premsrirut
Scott W Lowe
Protocols02 Feb 2012
Nature Protocols

Volume: 7, P: 374-393

Search

Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Erratum: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

Stage-specific control of early B cell development by the transcription factor Ikaros

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Metabolic gatekeeper function of B-lymphoid transcription factors

Tissue-specific and reversible RNA interference in transgenic mice

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

T-ALL can evolve to oncogene independence

A pipeline for the generation of shRNA transgenic mice

Search

Quick links

Search

Filter By:

Search

Quick links