Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
A slow earthquake sequence on the San Andreas fault

Alan T. Linde
Michael T. Gladwin
Roger G. Bilham
Research05 Sept 1996
Nature

Volume: 383, P: 65-68
Authigenic magnetite formation in suboxic marine sediments

Robert Karlin
Mitchell Lyle
G. Ross Heath
Research01 Apr 1987
Nature

Volume: 326, P: 490-493
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome.

Catherine S. Storm
Demis A. Kia
Nicholas W. Wood
ResearchOpen Access20 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages.

Frederick C. Nucifora Jr
Leslie G. Nucifora
Christopher A. Ross
ResearchOpen Access07 Jun 2016
Nature Communications

Volume: 7, P: 1-11
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens
Sarah Edkins
Richard Wooster
Research22 May 2005
Nature Genetics

Volume: 37, P: 590-592
Exploring neuropsychiatric symptoms in Friedreich ataxia

Simona Karamazovova
Lucie Stovickova
Martin Vyhnalek
ResearchOpen Access23 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Amendments and Corrections13 Feb 2023
Nature Genetics

Volume: 55, P: 519-520
Sleep health composites are associated with the risk of heart disease across sex and race

Soomi Lee
Christina X. Mu
Sanjay R. Patel
ResearchOpen Access07 Feb 2022
Scientific Reports

Volume: 12, P: 1-11

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