Nature Search

RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

Katherine M Hannan
Brian K Kennedy
Lawrence I Rothblum
Research21 Jul 2000
Oncogene

Volume: 19, P: 3487-3497
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and overcomes PARPi resistance in PDX models of HGSOC.

Elaine Sanij
Katherine M. Hannan
Richard B. Pearson
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-18
Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients

SJ Wigmore
JS Falconer
KCH Fearon
Research01 Jul 1995
British Journal of Cancer

Volume: 72, P: 185-188
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.

Pei Y. Liu
Andrew E. Tee
Tao Liu
ResearchOpen Access05 Nov 2019
Nature Communications

Volume: 10, P: 1-17
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.

Marcus Lefebure
Richard W. Tothill
Ricky W. Johnstone
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-10
Factors associated with joint pain among postmenopausal women

C Huang
PD Ross
RD Wasnich
Research01 May 1997
International Journal of Obesity

Volume: 21, P: 349-354
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them in mouse models may provide a way to overcome this limitation.

Fotios Sampaziotis
Alexander W Justin
Ludovic Vallier
Research03 Jul 2017
Nature Medicine

Volume: 23, P: 954-963
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

C-terminal mutations in the XPB helicase subunit of TFIIH are associated with cancer. Here, using Drosophilamodels, the authors demonstrate C-terminally truncated Hay/XPB alleles enhance overgrowth dependent on Hfp, the orthologue of the MYC transcriptional repressor FIR.

Jue Er Amanda Lee
Naomi C. Mitchell
Leonie M. Quinn
Research15 Jun 2015
Nature Communications

Volume: 6, P: 1-12
Evidence of linkage to chromosomes 10p15.3–p15.1, 14q24.3–q31.1 and 9q33.3–q34.3 in non-syndromic colorectal cancer families

Ian W Saunders
Jason Ross
Garry N Hannan
Research10 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 91-96
The renin–angiotensin system and cancer: old dog, new tricks

This Review describes the evidence linking the renin–angiotensin system (RAS) to cancer, through its roles in processes such as apoptosis, angiogenesis and tissue remodelling. Could RAS inhibitors currently used in the clinic be retooled to treat cancer?

Amee J. George
Walter G. Thomas
Ross D. Hannan
Reviews22 Oct 2010
Nature Reviews Cancer

Volume: 10, P: 745-759
Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Increasing evidence indicates that components of the RNA polymerase complexes are altered in cancer. This Review discusses how all three classes of human RNA polymerase activity are dysregulated in cancer and the opportunities to therapeutically target RNA polymerase activity.

Megan J. Bywater
Richard B. Pearson
Ross D. Hannan
Reviews24 Apr 2013
Nature Reviews Cancer

Volume: 13, P: 299-314
A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T. Chan
Shaun Blake
Richard B. Pearson
ResearchOpen Access08 Jul 2019
Cell Death & Differentiation

Volume: 27, P: 725-741
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers
Victoria W. Wen
Michelle J. Henderson
ResearchOpen Access22 Jan 2019
Oncogene

Volume: 38, P: 3824-3842
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Shunfei Yan
Jiachen Xuan
Keefe T. Chan
ResearchOpen Access11 Nov 2020
British Journal of Cancer

Volume: 124, P: 616-627
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch et al. report the changes in rDNA chromatin state associated with cell transition into malignancy. They show that a specific transcription factor regulates this transition by altering rDNA chromatin, resulting in the reorganization of contacts between rDNA and the genome.

Jeannine Diesch
Megan J. Bywater
Gretchen Poortinga
ResearchOpen Access28 Jan 2019
Communications Biology

Volume: 2, P: 1-14
Targeting RNA polymerase I to treat MYC-driven cancer

G Poortinga
L M Quinn
R D Hannan
Reviews10 Mar 2014
Oncogene

Volume: 34, P: 403-412
The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

M D Barber
D C McMillan
K C H Fearon
ResearchOpen Access02 Mar 2004
British Journal of Cancer

Volume: 90, P: 1129-1132
An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition

Jason Ross
Linda Lockett
Garry N Hannan
Research27 Mar 2013
European Journal of Human Genetics

Volume: 21, P: 1389-1395

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RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Factors associated with joint pain among postmenopausal women

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

Evidence of linkage to chromosomes 10p15.3–p15.1, 14q24.3–q31.1 and 9q33.3–q34.3 in non-syndromic colorectal cancer families

The renin–angiotensin system and cancer: old dog, new tricks

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

A functional genetic screen defines the AKT-induced senescence signaling network

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Targeting RNA polymerase I to treat MYC-driven cancer

The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition

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