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Showing 1–4 of 4 results
Advanced filters: Author: Rossella Libé Clear advanced filters

  • Adrenocortical carcinomas (ACC) are aggressive and often resistant to therapy. Here, the authors provide a single-nucleus transcriptomic atlas of ACCs and normal adrenal glands, finding ecotypes in steroid and microenvironment cells that are associated with clinical outcomes.

    • Anne Jouinot
    • Yoann Martin
    • Guillaume Assié
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare neuroendocrine tumours with a significant genetic component. Here, the authors carry out a multi-omic integrative characterization of PCC/PGL and reveal potential genomic alterations and regulatory mechanisms involved in the disease.

    • Luis Jaime Castro-Vega
    • Eric Letouzé
    • Anne-Paule Gimenez-Roqueplo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Adrenocortical carcinoma is a rare heterogeneous neoplasm with an incompletely understood pathogenesis and a poor prognosis. No general consensus on the diagnostic and therapeutic measures for adrenocortical carcinoma exists, but collaborative efforts have substantially advanced the field. This Review provides an updated approach to the patient with suspected adrenocortical carcinoma and discusses etiology, diagnosis and treatment options.

    • Martin Fassnacht
    • Rossella Libé
    • Bruno Allolio
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 323-335

  • Jérôme Bertherat, Aurélien de Reyniès and colleagues perform integrated genomic analyses of adrenocortical carcinomas. They discover recurrent alterations in several new driver genes, including ZNRF3, DAXX, TERT and MED12, and identify two distinct molecular subgroups with opposite clinical outcomes.

    • Guillaume Assié
    • Eric Letouzé
    • Jérôme Bertherat
    Research
    Nature Genetics
    Volume: 46, P: 607-612