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Showing 1–10 of 10 results
Advanced filters: Author: Ruby Gupta Clear advanced filters
  • Earth System Models are widely used for projecting future streamflow. The authors show that the models underestimate declines in global streamflow with climate change, indicating that a future water crisis could be more severe than previously estimated.

    • Yongqiang Zhang
    • Hongxing Zheng
    • Günter Blöschl
    Research
    Nature Water
    Volume: 1, P: 261-271
  • Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb−1.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature
    Volume: 633, P: 542-547
  • Wolfram syndrome, caused by WFS1 or CISD2 gene mutations, disrupts ER Ca2+ regulation in neurons. Here, the authors show how these mutations impair ER-mitochondria interactions, compromise Ca2+ transfer and mitochondrial function, and lead to bioenergetic deficits and oxidative stress.

    • Mailis Liiv
    • Annika Vaarmann
    • Allen Kaasik
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74
  • Joseph Gleeson and colleagues report whole-exome sequencing of a cohort of over 1,000 individuals from the Greater Middle East, characterizing common and rare variants. They find evidence of subregional diversity and historical migrations and use the GME Variome to identify disease-causing mutations.

    • Eric M Scott
    • Anason Halees
    • Joseph G Gleeson
    Research
    Nature Genetics
    Volume: 48, P: 1071-1076
  • Managing high-risk newborns with critical congenital heart disease (CCHD) in the delivery room is a unique challenge, characterized by complex physiology, heightened urgency, the coordinated efforts of multiple medical teams, and depending on the facility, the infrequent occurrence of such cases. Currently, there is a lack of unified guidance for resuscitation of these newborns in the delivery room. In this commentary, we advocate for an integrated approach involving maternal-fetal medicine specialists, fetal cardiologists, neonatologists, and cardiac intensivists. The proposed approach emphasizes collaborative pre-delivery planning, focusing on anticipated risk factors, postnatal physiology, and clinical management plans. We stress the importance of simulation-based education specifically addressing CCHD scenarios and advocate for research collaborations to establish evidence-based guidelines and track outcomes. Ultimately, a comprehensive, collaborative, and standardized approach, involving prenatal coordination, communication, and education, is essential for optimizing the delivery room management of neonates with CCHD.

    • Alyssa R. Thomas
    • Philip T. Levy
    • Noorjahan Ali
    Comments & Opinion
    Journal of Perinatology
    Volume: 44, P: 321-324