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Advanced filters: Author: Ruei-Liang Yan Clear advanced filters

TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation

cGAS/STING activation is linked to the induction of anti-tumor immune responses. Here the authors report a role for the deubiquitinating enzyme TRABID in regulating mitotic cell division and suppressing anti-tumor immunity, suggesting that TRABID inhibition induces micronuclei and activates cGAS/STING pathway.

Yu-Hsuan Chen
Han-Hsiun Chen
Ruey-Hwa Chen
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-20
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver.

Yu-Hsuan Chen
Tzu-Yu Huang
Ruey-Hwa Chen
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-19
Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration

Chia-Yi Su
Ruei-Liang Yan
Hong-Chen Chen
ResearchOpen Access23 Sept 2019
Scientific Reports

Volume: 9, P: 1-11

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