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Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Chensu Wang
Hanspeter Niederstrasser
Michael A. White
Amendments and CorrectionsOpen Access21 May 2018
Nature Communications

Volume: 9, P: 1
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the therapeutic efficacy of these compounds in mice and worms.

Chensu Wang
Hanspeter Niederstrasser
Michael A. White
ResearchOpen Access22 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Cell-cell coupling via gap junctions has been extensively studied in vitro and in heterologous systems, but in vivo studies are still few. A new class of photoactivatable bioconjugates is now used to monitor gap junctional coupling in living Caenorhabditis elegans.

Yan-Ming Guo
Shiuhwei Chen
Wen-hong Li
Research01 Aug 2008
Nature Methods

Volume: 5, P: 835-841
Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote mitochondrial function via Sirtuin1/5.

Esmaeil Dehghan
Mohammad Goodarzi
Hamid Mirzaei
ResearchOpen Access28 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-associated diseases more broadly.

Esmaeil Dehghan
Yiqiang Zhang
Hamid Mirzaei
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Policing rogue genes

Transposons are mobile chunks of DNA that insert themselves at random in the genome. This is dangerous, particularly in germline DNA (which is passed on to offspring). A new mechanism for suppressing transposon activity in the nematode worm Caenorhabditis elegans is proposed, and it involves the until-now mysterious phenomenon of RNA interference.

Rueyling Lin
Leon Avery
News & Views11 Nov 1999
Nature

Volume: 402, P: 128-129

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Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Policing rogue genes

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Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Policing rogue genes

Search

Quick links