B cells rearrange the immunoglobulin heavy chain genes to produce a functional B cell receptor, but how it is decided that one allele rearranges first is not clear. Here the authors provide evidence that in the majority of common lymphoid precursor clones, the two alleles have a similar probability of rearranging first.
- Clara F. Alves-Pereira
- Raquel de Freitas
- Vasco M. Barreto