Cytochrome P450 enzymes metabolize drugs and contribute to harmful drug-drug interactions. To decipher p450 activities, Veith et al. screen ∼17,000 compounds, including >1,000 FDA-approved drugs, against five important P450 isozymes and identify chemical structures that are enriched in compounds active against specific isozymes.
- Henrike Veith
- Noel Southall
- Douglas S Auld
