CRISPR-Cas systems are prokaryotic immune defenses commonly targeted by phage-encoded anti-CRISPR (Acr) proteins. Here, authors report cryo-EM structures of Cas2/3 and its complex with AcrIF19 from Pectobacterium atrosepticum, and uncover its dual inhibitory mechanism against Cas2/3 function.
- Yuanshuo Sa
- Chunlei Liu
- Yongchao Xie
