This study describes how HOTAIRM1 transferred by alveolar epithelial cell (AEC)-derived Exos promotes proliferation and transdifferentiation of lung fibroblasts. The authors reveal the mechanism by which HOTAIRM1 competitively binds to miR-30d-3p and YY1 to upregulate the expression of HSF1. Furthermore, AEC-Exosomes harboring HOTAIRM1 accelerates interstitial pulmonary fibrosis through disrupting miR-30d-3p-mediated HSF1 inhibition and inducing HSF1.
- Lin Chen
- Yang Yang
- XiaoBo Huang
