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Showing 1–17 of 17 results
Advanced filters: Author: Rumiana Dimova Clear advanced filters

  • Membrane lipid packing, influenced by cholesterol, lipid chain length, and saturation, regulates the affinity of biomolecular condensates, enhancing their interactions with less ordered membranes and driving membrane remodeling, including nanotube and double-membrane sheet formation.

    • Agustín Mangiarotti
    • Elias Sabri
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Membrane-adsorbed condensates are crucial for biomolecular localization and can induce significant changes in membrane morphology, but the underlying mechanisms remain underexplored. Here, the authors combine imaging experiments and coarse-grained simulations to study poly-Lysine/poly-Aspartate (K10/D10) coacervates with different unilamellar liposomes, showing that their membrane affinity can be tuned by the anionic lipid content and quantified through the intrinsic contact angle both in vitro and in silico.

    • Sayantan Mondal
    • Agustín Mangiarotti
    • Qiang Cui
    ResearchOpen Access
    Communications Chemistry
    Volume: 9, P: 1-12

  • Nano-environmental probes and advance imaging microscopy provide deep insight into protein phase separation and the interaction of condensates with membranes, revealing that wetting by condensates can modulate membrane lipid packing and hydration.

    • Agustín Mangiarotti
    • Macarena Siri
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Liquid–liquid phase separation (LLPS) within cells is a captivating phenomenon known to aid the organization of cellular components; however, its complex kinetics have remained a puzzle. Now, a new study elucidates the crosstalk between the phase state of an encapsulating membrane and LLPS dynamics.

    • Rumiana Dimova
    News & Views
    Nature Chemistry
    Volume: 16, P: 10-11

  • In this work, the authors investigated on the interaction of biomolecular condensates with membranes and report that they can exhibit two wetting transitions modulated by membrane or milieu composition. Condensate adhesion can trigger intriguing ruffling of the membrane interface into complex finger-like structures.

    • Agustín Mangiarotti
    • Nannan Chen
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Many bacterial toxins and viruses deform membranes prior to entering cells via clathrin independent endocytosis. Here the authors show that multivalent lipid binding by globular particles can exceed a threshold adhesion energy required for membrane deformation and that this is sufficient for internalization.

    • Raluca Groza
    • Kita Valerie Schmidt
    • Helge Ewers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Stress granules function at sites of intracellular membrane damage by forming on and stabilizing the ruptured membrane and promoting membrane repair.

    • Claudio Bussi
    • Agustín Mangiarotti
    • Maximiliano G. Gutierrez
    ResearchOpen Access
    Nature
    Volume: 623, P: 1062-1069

  • A variety of artificial cells springs from the functionalization of liposomes with proteins but these models suffer from low durability without repair and replenishment mechanisms. Here, the authors show that synthetic amphiphile membranes undergo SNARE-mediated fusion, and determine bending rigidity and pore edge tension as key parameters for fusion.

    • Lado Otrin
    • Agata Witkowska
    • Tanja Vidaković-Koch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1, fundamentally changing the study of biology2. The term biomolecular condensate refers to non-stoichiometric assemblies that are composed of multiple types of macromolecules in cells, occur through phase transitions, and can be investigated by using concepts from soft matter physics3. As such, they are intimately related to aqueous two-phase systems4 and water-in-water emulsions5. Condensates possess tunable emergent properties such as interfaces, interfacial tension, viscoelasticity, network structure, dielectric permittivity, and sometimes interphase pH gradients and electric potentials6–14. They can form spontaneously in response to specific cellular conditions or to active processes, and cells appear to have mechanisms to control their size and location15–17. Importantly, in contrast to membrane-enclosed organelles such as mitochondria or peroxisomes, condensates do not require the presence of a surrounding membrane.

    • Simon Alberti
    • Paolo Arosio
    • Tanja Mittag
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Steinkühler et al. use giant plasma membrane vesicles as a model system to study how plasma membranes respond to environmental changes, employing fluctuation spectroscopy and fluorescent probes. They show that the bending rigidity of plasma membranes vary with lipid order and microviscosity in correlated manner.

    • Jan Steinkühler
    • Erdinc Sezgin
    • Rumiana Dimova
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-8