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Showing 1–5 of 5 results
Advanced filters: Author: Runrun Wu Clear advanced filters

  • The β-barrel assembly machinery (BAM) assists the folding and membrane insertion of bacterial outer membrane proteins. Here, the authors report structural characterization of BAM in lipid environment and in complex with the client protein EspP integrated into the barrel of BamA, providing insight into BAM mechanism of function.

    • Runrun Wu
    • Jeremy W. Bakelar
    • Nicholas Noinaj
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The human defense mechanism against pathogens involves limiting essential nutrients, such as zinc which is countered by surface receptor TdfH pirating zinc from human calprotectin. The TdfH cryo-EM structure from N. gonorrhoeae in complex with a calprotectin tetramer provides insights into the protein-protein interaction and the role of metal ions.

    • Aloke K. Bera
    • Runrun Wu
    • Nicholas Noinaj
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-6

  • Colonization of trypsin-degrading commensal bacteria may contribute to the maintenance of intestinal homeostasis and protection against pathogen infection in humans and mice.

    • Youxian Li
    • Eiichiro Watanabe
    • Kenya Honda
    ResearchOpen Access
    Nature
    Volume: 609, P: 582-589

  • Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.

    • Yu Imai
    • Kirsten J. Meyer
    • Kim Lewis
    Research
    Nature
    Volume: 576, P: 459-464