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Showing 1–2 of 2 results
Advanced filters: Author: Runxiang Qiu Clear advanced filters

  • Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.

    • Runxiang Qiu
    • Jun Wu
    • Qiang Lu
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

    • Anqi Geng
    • Runxiang Qiu
    • Qiang Lu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16