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Advanced filters: Author: Runying Y. Yang Clear advanced filters

Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

Zequn Lu
Can Chen
Xiaoping Miao
Research25 Aug 2025
Nature Cancer

Volume: 6, P: 1777-1799
Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations

Kv1.2 is a voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. Here authors use electrophysiology and find that Slc7a5, a neutral amino acid transporter, has a profound impact on Kv1.2.

Victoria A. Baronas
Runying Y. Yang
Harley T. Kurata
ResearchOpen Access24 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Extracellular redox sensitivity of Kv1.2 potassium channels

Victoria A. Baronas
Runying Y. Yang
Harley T. Kurata
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-10