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Showing 1–5 of 5 results
Advanced filters: Author: Ruocheng Li Clear advanced filters

  • Application of CRISPR-Cas13d is limited by the inability to predict on- and off-targets. Here the authors perform CRISPR-Cas13d proliferation screens followed by modeling of Cas13d on- and off-targets; they design a deep learning model, DeepCas13, to predict the on-target activity of a gRNA.

    • Xiaolong Cheng
    • Zexu Li
    • Wei Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Inorganic nanoparticles can accumulate in living organisms causing a dose-dependent increase in cellular reactive oxygen species. Here, the authors leverage this as a potential scheme for regulating metabolic disorders, showing that that low-dose nanoparticle administration can enhance lipid hydrolysis and alleviate fatty liver.

    • Jie Cai
    • Jie Peng
    • Diming Wang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Nationwide citizen science data show the importance of farmland outside protected areas for China’s avifauna. We urge the government of China to develop a national strategy for policy and research to protect biodiversity and traditional knowledge of sustainable agriculture to meet the post-2020 goal of the Convention on Biological Diversity.

    • Li Li
    • Ruocheng Hu
    • Zhi Lü
    Comments & Opinion
    Nature Ecology & Evolution
    Volume: 4, P: 772-774

  • Despite the potential of fluorinated compounds in pharmaceuticals and agrochemicals, the formation of C–F bonds remains challenging. It has now been shown that aryl sulfonium salts, which can be made by site-selective C–H functionalization, have advantageous photoredox reactivity compared to conventional (pseudo)halides and can be used for late-stage C–H fluorination.

    • Jiakun Li
    • Junting Chen
    • Tobias Ritter
    Research
    Nature Chemistry
    Volume: 12, P: 56-62