Biocatalysis has been widely employed for the generation of carbon-carbon/heteroatom stereocenters, yet its application in chiral C(sp3)–S bond construction is rare. Herein, the authors describe the enantioselective construction of chiral C(sp3)–S bonds through ene-reductase biocatalysed conjugate reduction of prochiral vinyl sulfides.
- Fei Zhao
- Ariane Mattana
- Daniele Castagnolo
