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Showing 1–2 of 2 results
Advanced filters: Author: Russell C. Levack Clear advanced filters

  • Endosomal TLR7 and TLR9 recognize RNA and DNA ligands, respectively, and both signal via MyD88 yet appear to play opposing roles in autoimmunity. Shlomchik and colleagues examine this TLR ‘paradox’, reporting that TLR9 has two protective functions, including an as yet unidentified additional MyD88-independent signaling pathway that confers protection against autoimmunity.

    • Claire Leibler
    • Shinu John
    • Mark J. Shlomchik
    Research
    Nature Immunology
    Volume: 23, P: 1457-1469

  • CD11c+T-bet+ B cells have been linked with different autoimmune diseases, but targeting these cells has been challenging. Here the authors use an adenosine 2A receptor agonist to deplete these B cells and to inhibit or reverse autoimmune symptoms and pathology in mice.

    • Russell C. Levack
    • Krista L. Newell
    • Gary M. Winslow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12