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Showing 1–6 of 6 results
Advanced filters: Author: Ruth A. Pumroy Clear advanced filters

  • A non-selective calcium channel transient receptor potential vanilloid 2 (TRPV2) is a potential drug target. Here, the authors employ cryo-electron microscopy, in silico docking, and electrophysiology to identify a binding site for an activator 2-aminoethoxydiphenyl borate (2-APB) in this channel.

    • Ruth A. Pumroy
    • Anna D. Protopopova
    • Vera Y. Moiseenkova-Bell
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

    • Taylor E. T. Hughes
    • Ruth A. Pumroy
    • Vera Y. Moiseenkova-Bell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an activated conformation, providing insights into potential therapeutic applications.

    • Julia A. Rocereta
    • Toni Sturhahn
    • Vera Moiseenkova-Bell
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1019-1029

  • Here, using cryo-EM, the authors reveal the mechanism by which RecA filamented on single-stranded DNA binds to and induces LexA cleavage, the key signal governing the bacterial DNA damage response pathway implicated in antibiotic resistance.

    • Michael B. Cory
    • Allen Li
    • Rahul M. Kohli
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1522-1531

  • Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.

    • Rajeshwer S. Sankhala
    • Ravi K. Lokareddy
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • High-speed AFM enables visualization of intrinsically disordered regions (IDRs) in TRP ion channels and shows that IDRs may mediate protein-protein interactions with adjacent TRP molecules.

    • Raghavendar R. Sanganna Gari
    • Grigory Tagiltsev
    • Simon Scheuring
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-10