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Showing 1–9 of 9 results
Advanced filters: Author: Ruth Ann Marrie Clear advanced filters
  • Comorbidity is common in multiple sclerosis (MS). In this Opinion article, Ruth Ann Marrie discusses how comorbidity affects diagnosis, progression, mortality, and health-related quality of life in patients with MS, and how clinicians should incorporate the prevention and management of comorbidities when treating MS.

    • Ruth Ann Marrie
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 375-382
  • In this Roadmap, Marrie and colleagues set out the steps needed to improve our understanding of the multiple sclerosis (MS) prodrome and develop standardized criteria for identifying individuals with prodromal MS, thereby facilitating trials of interventions that could slow progression to classical MS.

    • Ruth Ann Marrie
    • Mark Allegretta
    • Helen Tremlett
    Reviews
    Nature Reviews Neurology
    Volume: 18, P: 559-572
  • Approximately half of the people currently with multiple sclerosis (MS) are ≥50 years of age, yet guidelines for management of MS in older age are lacking. This Consensus statement presents the outcomes of an International Advisory Committee on Clinical Trials (IACCT) in MS workshop on ageing and MS, including recommendations for advancing research, care and awareness.

    • Anneke van der Walt
    • Eva M. M. Strijbis
    • Yinan Zhang
    Reviews
    Nature Reviews Neurology
    Volume: 21, P: 432-448
  • A new study provides direct biological evidence for a prodromal phase of multiple sclerosis (MS), with implications for studying disease aetiology and underscoring the limitations of therapies that solely target inflammation. The findings also suggest an opportunity to apply secondary prevention strategies at the very earliest stages of the disease.

    • Ruth Ann Marrie
    News & Views
    Nature Reviews Neurology
    Volume: 15, P: 689-690
  • Interferons are naturally occurring proteins with antiviral, antiproliferative, antineoplastic and immunomodulatory actions. This article reviews the findings of a series of clinical trials conducted between 1987 and 1997, which showed that interferon-β has beneficial effects on relapses and short-term disability in patients with multiple sclerosis.

    • Ruth Ann Marrie
    • Richard A Rudick
    Reviews
    Nature Clinical Practice Neurology
    Volume: 2, P: 34-44
  • Mirza et al. assess the relationship between diet, the gut microbiota, and pediatric-onset multiple sclerosis. They observe that a higher Mediterranean diet score and nutrient intakes, such as fiber, are associated with a lower odds of having multiple sclerosis, and that the gut microbiota might mediate this protective relationship.

    • Ali I. Mirza
    • Feng Zhu
    • Helen Tremlett
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-10