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Showing 1–6 of 6 results
Advanced filters: Author: Ruud Hovius Clear advanced filters

  • Silencing of endogenous retroviral elements (ERVs) is mediated by KAP1. Here, the authors describe the molecular mechanism by which KAP1 induces structural reorganization and multimerization of HP1α and maintains inaccessible chromatin at ERVs in mouse embryonic stem cells.

    • Nitika Gaurav
    • Ryan O’Hara
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Using cryo-electron microscopy, the authors determine the structure of cGAS bound to nucleosomes and present evidence for the mechanism by which nucleosome binding to cGAS prevents cGAS dimerization and its binding to free double-stranded DNA.

    • Ganesh R. Pathare
    • Alexiane Decout
    • Andrea Ablasser
    Research
    Nature
    Volume: 587, P: 668-672

  • The first X-ray crystal structure of the mouse serotonin 5-HT3 receptor, a pentameric ligand-gated ion channel, is similar to those of other Cys-loop receptors — though here electron density for part of the cytoplasmic domain, which is important for trafficking, synaptic localization, and modulation by cytoplasmic proteins, but not visible in previous structures, is also described.

    • Ghérici Hassaine
    • Cédric Deluz
    • Hugues Nury
    Research
    Nature
    Volume: 512, P: 276-281

  • Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.

    • Shiyu Chen
    • Ranganath Gopalakrishnan
    • Christian Heinis
    Research
    Nature Chemistry
    Volume: 6, P: 1009-1016

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477