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Showing 1–4 of 4 results

Advanced filters: Author: Ruud van Zessen Clear advanced filters

Dual action of ketamine confines addiction liability

Experiments in mice show that although ketamine has positive reinforcement properties, which are driven by its action on the dopamine system, it does not induce the synaptic plasticity that is typically observed with addiction.

Linda D. Simmler
Yue Li
Christian Lüscher
Research27 Jul 2022
Nature

Volume: 608, P: 368-373
A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.

Jeroen P. H. Verharen
Johannes W. de Jong
Louk J. M. J. Vanderschuren
ResearchOpen Access21 Feb 2018
Nature Communications

Volume: 9, P: 1-15
Stochastic synaptic plasticity underlying compulsion in a model of addiction

In mice, synaptic potentiation of transmission from the orbitofrontal cortex to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.

Vincent Pascoli
Agnès Hiver
Christian Lüscher
Research19 Dec 2018
Nature

Volume: 564, P: 366-371
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits

Dennis R Sparta
Alice M Stamatakis
Garret D Stuber
Protocols08 Dec 2011
Nature Protocols

Volume: 7, P: 12-23