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Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Susan Pereira Ribeiro
Zachary Strongin
Rafick P. Sekaly
Amendments and CorrectionsOpen Access16 Jan 2025
Nature Immunology

Volume: 26, P: 524
CD8⁺ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production

Control of HIV and SIV infection is largely thought to be achieved through direct lysis of target cells. Here, using mathematical modelling of viral load data from rhesus macaques, the authors propose that virus control is best explained by the combination of cytolytic and non-cytolytic effects.

Benjamin B. Policicchio
Erwing Fabian Cardozo-Ojeda
Ruy M. Ribeiro
ResearchOpen Access20 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

When monkeys are infected with a virus similar to HIV, treated with antiretroviral therapy (ART), and are administered a ‘combo therapy’ made of antibodies against molecules that inhibit immune responses, they control viral rebound when ART is discontinued for more than 6 months

Susan Pereira Ribeiro
Zachary Strongin
Rafick P. Sekaly
ResearchOpen Access12 Sept 2024
Nature Immunology

Volume: 25, P: 1900-1912
Quantifying the activity of anti-HIV treatment in silico

Combination-based antiretroviral therapy has been very successful in preventing disease progression in HIV-infected individuals. However, a rational method for predicting the effect of a particular drug combination on clinical outcome is needed. A new study takes us closer to this goal by computationally predicting the inhibitory effects of combinations of three antiretroviral drugs (pages 446–451).

Ruy M Ribeiro
News & Views06 Mar 2012
Nature Medicine

Volume: 18, P: 355-356
Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

In April 2021, Eli Lilly voluntarily asked the FDA to revoke the Emergency Use Authorization for the monoclonal antibody bamlanivimab due to reduced susceptibility in vitro to SARS-CoV-2 variants, not for safety. In this work, authors carry out a placebo-controlled phase 2 evaluation of bamlanivimab in non-hospitalized adults with COVID-19, to determine safety and efficacy.

Kara W. Chew
Carlee Moser
Davey M. Smith
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-12
Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial

This Article reports the emergence of SARS-CoV-2 escape mutations during bamlanivimab therapy in the setting of a phase II clinical trial.

Manish C. Choudhary
Kara W. Chew
Akbar Shahkolahi
Research26 Oct 2022
Nature Microbiology

Volume: 7, P: 1906-1917
Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

Kara W. Chew
Carlee Moser
Davey M. Smith
Amendments and CorrectionsOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1
Illuminating a blind spot in SARS-CoV-2 immunity

Indigenous populations are disproportionately affected by COVID-19, but are rarely studied. An investigation of the immune response of Australian First Nations people to SARS-CoV-2 vaccination and infection shows a major effect of comorbidities.

Luis Graca
Ana Caetano Faria
Ruy M. Ribeiro
News & Views29 May 2023
Nature Immunology

Volume: 24, P: 889-890
High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Sayera Dhaubhadel
Kumkum Ganguly
Benjamin H. McMahon
ResearchOpen Access20 Jan 2024
Scientific Reports

Volume: 14, P: 1-19
HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

Persistence of HIV is attributed primarily to latent infection of CD4⁺ T cells. Honeycutt et al. report that in humanized mice lacking T cells HIV can rebound from myeloid cells after antiretroviral treatment interruption, suggesting that persistence of HIV could involve other cell types.

Jenna B Honeycutt
William O Thayer
J Victor Garcia
Research17 Apr 2017
Nature Medicine

Volume: 23, P: 638-643
Post-recovery viral shedding shapes wastewater-based epidemiological inferences

Phan et al. assess the impact of prolonged viral shedding on epidemiological inferences based on wastewater data. They find that as more infected individuals recover during an outbreak, virus shed by the recovered population increases, which, if not accounted for, can lead to inaccurate epidemiological inferences.

Tin Phan
Samantha Brozak
Fuqing Wu
ResearchOpen Access22 May 2025
Communications Medicine

Volume: 5, P: 1-10
A simple model of COVID-19 explains disease severity and the effect of treatments

Steven Sanche
Tyler Cassidy
Ruian Ke
ResearchOpen Access20 Aug 2022
Scientific Reports

Volume: 12, P: 1-14
Telemonitoring of daily activities compared to the six-minute walk test further completes the puzzle of oximetry-guided interventions

Catarina Duarte Santos
Ana Filipe Santos
Cristina Bárbara
ResearchOpen Access16 Aug 2021
Scientific Reports

Volume: 11, P: 1-10

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Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

CD8⁺ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Quantifying the activity of anti-HIV treatment in silico

Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial

Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

Illuminating a blind spot in SARS-CoV-2 immunity

High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

Post-recovery viral shedding shapes wastewater-based epidemiological inferences

A simple model of COVID-19 explains disease severity and the effect of treatments

Telemonitoring of daily activities compared to the six-minute walk test further completes the puzzle of oximetry-guided interventions

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