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Showing 1–10 of 10 results
Advanced filters: Author: Ryan Birol Clear advanced filters

  • The ability to control the magnetic order in a material with an electric field will enable low-power non-volatile memories and new types of computer logic. Ryanet al. demonstrate that europium titanate under moderate strain exhibits strong magnetoelectric coupling that could be valuable to this endeavour.

    • P. J. Ryan
    • J-W Kim
    • D. G. Schlom
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Several genomic features have been found for acute myeloid leukaemia (AML) but targeted clinical genetic testing fails to predict prognosis. Here, the authors generate an AML prognostic score from RNA-seq data of patients, which successfully stratifies AML patients and which may provide guidance for therapeutic strategies.

    • T. Roderick Docking
    • Jeremy D. K. Parker
    • Aly Karsan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A new family of tunable microwave dielectrics with unparalleled performance at frequencies up to 125 GHz at room temperature has been created, using dimensionality to add and control a local ferroelectric instability in a system with exceptionally low dielectric loss.

    • Che-Hui Lee
    • Nathan D. Orloff
    • Darrell G. Schlom
    Research
    Nature
    Volume: 502, P: 532-536

  • The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.

    • Donna M. Muzny
    • Matthew N. Bainbridge
    • Elizabeth Thomson.
    ResearchOpen Access
    Nature
    Volume: 487, P: 330-337

  • The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

    • Daniel C. Koboldt
    • Robert S. Fulton
    • Jacqueline D. Palchik
    ResearchOpen Access
    Nature
    Volume: 490, P: 61-70

  • Marco Marra and colleagues identify somatic mutations in EZH2 in diffuse large B-cell lymphomas and follicular lymphomas. EZH2 is a histone methyltransferase that participates in trimethylation of H3 Lys27 (H3K27) as part of the PRC2 complex. The mutations alter a single tyrosine residue in the SET domain of EZH2 and reduce the ability of PRC2 to trimethylate H3K27 in vitro.

    • Ryan D Morin
    • Nathalie A Johnson
    • Marco A Marra
    Research
    Nature Genetics
    Volume: 42, P: 181-185

  • Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.

    • Kyle Chang
    • Chad J Creighton
    • Joshua M Stuart
    Comments & OpinionOpen Access
    Nature Genetics
    Volume: 45, P: 1113-1120