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Showing 1–11 of 11 results
Advanced filters: Author: Ryan D. Hoyle Clear advanced filters

  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322

  • Investment in watershed services programs is growing, however the factors that contribute to sustainability of such programs are unclear. Here the authors use a large database of cities around the world to show that payment schemes are more likely to be present in watersheds with more agricultural land and less protected areas.

    • Chelsie L. Romulo
    • Stephen Posner
    • Robert I. McDonald
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

    • Robert D. Burk
    • Zigui Chen
    • David Mutch
    ResearchOpen Access
    Nature
    Volume: 543, P: 378-384

  • Mannose reduces the growth of tumour cells by impairing the metabolism of glucose, and enhances cell death when used in combination with conventional chemotherapy.

    • Pablo Sierra Gonzalez
    • James O’Prey
    • Kevin M. Ryan
    Research
    Nature
    Volume: 563, P: 719-723

  • The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.

    • Donna M. Muzny
    • Matthew N. Bainbridge
    • Elizabeth Thomson.
    ResearchOpen Access
    Nature
    Volume: 487, P: 330-337

  • The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

    • Daniel C. Koboldt
    • Robert S. Fulton
    • Jacqueline D. Palchik
    ResearchOpen Access
    Nature
    Volume: 490, P: 61-70

  • Sanchez, Rokhsar, and colleagues use genome skimming to generate DNA markers for phylogenomic analyses of bobtail and bottletail squid. The ancestral state of bioluminescence suggests that the Sepiolinae ancestor possessed a bilobed light organ with bacteriogenic luminescence. Also, analyses of divergence time suggest that major biogeographic events might have shaped the speciation of these animals.

    • Gustavo Sanchez
    • Fernando Á. Fernández-Álvarez
    • Daniel S. Rokhsar
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9

  • Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.

    • Kyle Chang
    • Chad J Creighton
    • Joshua M Stuart
    Comments & OpinionOpen Access
    Nature Genetics
    Volume: 45, P: 1113-1120