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Advanced filters: Author: Ryan De Bose-Boyd Clear advanced filters

  • Cryo-EM structural work shows sterols binding at four adjacent locations within the class F GPCR Smoothened (SMO), where the transmembrane core functions as a sterol tunnel in which occupancy activates SMO for downstream Hedgehog signaling.

    • Xiaofeng Qi
    • Lucas Friedberg
    • Xiaochun Li
    Research
    Nature Chemical Biology
    Volume: 16, P: 1368-1375