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Showing 1–3 of 3 results
Advanced filters: Author: Ryan Dykstra Clear advanced filters

  • As aromatic compounds can be obtained easily, their functionalization is a cornerstone of organic synthesis. Here, the authors report a dearomatization of aromatic isocyanides, installing three carbon-carbon bonds, two quaternary stereocenters, and three orthogonal functionalities in one operation.

    • Bilal Altundas
    • Embarek Alwedi
    • Fraser F. Fleming
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • The bicyclo[1.1.1]pentane (BCP) motif has drawn increasing attention recently in drug discovery. Now, a programmable bis-functionalization strategy has been developed to modularly access bridge-substituted BCP scaffolds, based on the inherent chemoselectivity of BCP bis-boronates (3° > 2°). This strategy should enable further structure–activity relationship studies of BCP-containing drug candidates and open the door to unexplored chemical space.

    • Yangyang Yang
    • Jet Tsien
    • Tian Qin
    Research
    Nature Chemistry
    Volume: 16, P: 285-293

  • Direct and stereospecific C(sp3)–C(sp2) cross-coupling reactions are highly desirable for the construction of complex molecular scaffolds. Now, using stable and easily accessible alkyl sulfinates as coupling reagents, a modular and programmable sulfurane-mediated coupling method has been developed for the installation of various hindered alkyl bioisosteres, such as trifluoromethyl cyclopropyl, to (hetero)aromatics.

    • Min Zhou
    • Jet Tsien
    • Tian Qin
    Research
    Nature Chemistry
    Volume: 15, P: 550-559