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Showing 1–3 of 3 results
Advanced filters: Author: Ryan Elbashir Clear advanced filters

  • Diehl et al. show that imbalance among nucleotide species is not sensed by canonical metabolic regulatory pathways, causing excessive cell growth despite a DNA replication block. ATR is needed to increase nucleotide availability in normal S phase.

    • Frances F. Diehl
    • Teemu P. Miettinen
    • Matthew G. Vander Heiden
    ResearchOpen Access
    Nature Cell Biology
    Volume: 24, P: 1252-1264

  • The recent approval of the first RNA interference (RNAi)-based therapy has generated considerable excitement in the field. Here, Rossi and colleagues discuss key advances in the design and development of RNAi drugs leading up to this landmark achievement, assess the current clinical pipeline and highlight future opportunities and challenges for RNAi-based therapeutics.

    • Ryan L. Setten
    • John J. Rossi
    • Si-ping Han
    Reviews
    Nature Reviews Drug Discovery
    Volume: 18, P: 421-446