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Showing 1–9 of 9 results
Advanced filters: Author: Ryan Garrity Clear advanced filters

  • In the context of succinate uptake to promote adipose tissue browning, Reddy, Winther et al. show how the directionality of succinate transport across membranes is coupled with metabolic flux-derived changes in pH gradients.

    • Anita Reddy
    • Sally Winther
    • Edward T. Chouchani
    Research
    Nature Metabolism
    Volume: 6, P: 567-577

  • In a cynomolgus macaque model, CRISPR base editors delivered in lipid nanoparticles are shown to efficiently and stably knock down PCSK9 in the liver to reduce levels of PCSK9 and low-density lipoprotein cholesterol in the blood.

    • Kiran Musunuru
    • Alexandra C. Chadwick
    • Sekar Kathiresan
    Research
    Nature
    Volume: 593, P: 429-434

  • The mitochondrial ADP/ATP carrier mediates the proton leak in mitochondria from all tissues that lack UCP1, thereby linking coupled (ATP production) and uncoupled (thermogenesis) energy conversion.

    • Ambre M. Bertholet
    • Edward T. Chouchani
    • Yuriy Kirichok
    Research
    Nature
    Volume: 571, P: 515-520

  • Common protonophores—previously known as protein-independent proton translocators—activate mitochondrial heat production due to H+ leak through the ADP/ATP carrier and uncoupling protein 1.

    • Ambre M. Bertholet
    • Andrew M. Natale
    • Yuriy Kirichok
    Research
    Nature
    Volume: 606, P: 180-187

  • UCP1 is exclusively expressed in brown and beige adipocytes, where it drives thermogenesis through futile substrate cycling. Mills et al. identify a endocrine pathway mediated by the UCP1 catabolic circuit that antagonizes liver inflammation by lowering the concentration of succinate in the liver extracellular fluid.

    • Evanna L. Mills
    • Cathal Harmon
    • Edward T. Chouchani
    Research
    Nature Metabolism
    Volume: 3, P: 604-617

  • The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.

    • Uri Ben-David
    • Benjamin Siranosian
    • Todd R. Golub
    Research
    Nature
    Volume: 560, P: 325-330

  • Climate-smart agriculture (CSA) is an approach to the development of agricultural systems intended to help support food security under climate change. This Perspective outlines a set of CSA actions needed from public, private and civil society stakeholders: building evidence; increasing local institutional effectiveness; fostering coherence between climate and agricultural policies; and linking climate and agricultural financing.

    • Leslie Lipper
    • Philip Thornton
    • Emmanuel F. Torquebiau
    Reviews
    Nature Climate Change
    Volume: 4, P: 1068-1072