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Advanced filters: Author: Ryan Pileski Clear advanced filters

  • Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of mutation stabilized HCA2, to describe the mechanism of HCA2 signaling.

    • Yang Yang
    • Hye Jin Kang
    • Zhi-Jie Liu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11