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Showing 1–4 of 4 results
Advanced filters: Author: Ryan Zenhausern Clear advanced filters

  • Lipid nanoparticles (LNPs) delivering mRNA after intratumoral administration could be a promising cancer treatment strategy. Here this group reports the intratumoral delivery of mRNA with LNPs inducing the expression of purine nucleoside phosphorylase and inhibiting the progression of head and neck squamous cell carcinoma in vivo.

    • Sebastian G. Huayamares
    • Liming Lian
    • James E. Dahlman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Stereochemistry can affect the reactivity and transport properties of small molecules; however, it is unclear whether the stereochemistry of components in a lipid nanoparticle influences its activity in vivo. Now, it has been shown that lipid nanoparticles made with a stereopure component can increase delivery of mRNA. A biological mechanism driving the effect is also proposed.

    • Marine Z. C. Hatit
    • Curtis N. Dobrowolski
    • James E. Dahlman
    Research
    Nature Chemistry
    Volume: 15, P: 508-515