The histone demethylase JHDM1B represses expression of the ribosomal RNA genes by demethylating the trimethylated lysine 4 residue of histone H3. This effect on rRNA expression is correlated with proliferation defects, and so reduced levels of JHDM1B may contribute to tumour development.
- David Frescas
- Daniele Guardavaccaro
- Michele Pagano