The post-translational modifications of histone tails generate a 'histone code' that defines local and global chromatin states. Here it is shown that nuclear GlcNAcylation of a histone lysine methyltransferase, MLL5, by O-linked β-N-acetylglucosamine transferase, facilitates retinoic-acid-induced granulopoiesis.
- Ryoji Fujiki
- Toshihiro Chikanishi
- Shigeaki Kato
